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Manufacturer

AMB HK Enterprises Inc

Origin of Medicine

India

Packing Type

Lyophilized Powder for Inj. (IV) in Vial

Salt Composition
       :  Decitabine

Description

Decitabine is a chemotherapy medication that reduces the growth of cancer cells. It treats myelodysplastic syndromes (MDS) like acute myeloid leukemia. MDS happens when your blood stem cells don’t become healthy blood cells.

Uses

  • Myelodysplastic syndromes (MDS): A group of cancers in which immature blood cells in the bone marrow do not mature and do not become healthy blood cells.
  • Chronic myelomonocytic leukemia (CMML): A type of MDS.
  • Certain types of anemia.

Side Effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Decitabine may cause serious side effects. Call your doctor at once if you have:

  • fever, chills, sore throat;
  • mouth sores, red or swollen gums, skin sores;
  • easy bruising, unusual bleeding, purple or red spots under your skin;
  • pale skin, cold hands and feet; or
  • cough with mucus, chest pain, feeling short of breath.

Common side effects of decitabine may include:

  • fever or other signs of infection.

Works

Decitabine is in a class of medications called hypomethylation agents, which help the bone marrow produce normal blood cells and kill abnormal cells in the bone marrow. It is given to help increase blood cell counts, reduce the risk of infection, reduce the amount of blood transfusions needed, decrease the risk of bleeding, and to prevent MDS from transforming to acute leukemia. Decitabine kills abnormal cells in the bone marrow by inhibiting a process called DNA methylation, which is essential for cell reproduction.

Direction of Use

  • Decitabine is given as an infusion into a vein. A healthcare provider will give you this injection.
  • In most cases, a decitabine injection is given every 8 hours for 3 days. This 3-day treatment is usually repeated every 6 weeks at least 4 times.
  • You may be given other medications to prevent nausea or vomiting while you are receiving decitabine.
  • Decitabine affects your immune system. You may get infections more easily, even serious or fatal infections. Your doctor will need to examine you on a regular basis.

Warning and Precaution

Tell your doctor if you have ever had:

  • kidney disease; or
  • liver disease.

You may need to have a negative pregnancy test before starting this treatment.

Decitabine can harm an unborn baby or cause birth defects if the mother or the father is using decitabine.

  • If you are a woman, do not use decitabine if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.
  • If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.
  • Tell your doctor right away if a pregnancy occurs while either the mother or the father is using decitabine.

This medicine may affect fertility (ability to have children) in men. However, it is important to use birth control to prevent pregnancy because decitabine can harm an unborn baby.

You should not breastfeed while using decitabine and for at least 2 weeks after your last dose.

FAQ

Q1. What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your decitabine injection.

Q2. What happens if I overdose?

Since decitabine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

Q3. What should I avoid while receiving decitabine?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.

Q4. What other drugs will affect decitabine?

Other drugs may affect decitabine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

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