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Manufacturer

Venus Remedies Limited

Origin of Medicine

India

Packing Type

Lyophilized Powder for Inj. (IV) in Vial

Salt Composition
       :  Zoledronic Acid [OOS]

Description

Zoledronic acid is a medication that belongs to the class of medicines known as bisphosphonates. It is used to treat Paget’s disease and osteoporosis. Zoledronic acid works by inhibiting osteoclasts, which are responsible for breaking down and reabsorbing bone. It also inhibits increased osteoclastic activity and the release of calcium by the skeleton induced by tumors. This helps to slow bone breakdown, increase bone density, and decrease the amount of calcium released from the bones into the blood.

Uses

Zoledronic acid strengthens bones and is used for the treatment or prevention of osteoporosis. It works by inhibiting osteoclasts, the cells responsible for breaking down and reabsorbing bone through a process known as bone resorption. Additionally, it helps prevent increased osteoclastic activity and the release of calcium from the skeleton, which can be induced by tumors. Zoledronic acid belongs to a class of medications known as bisphosphonates.

Side Effects

Get emergency medical help if you have signs of an allergic reaction: hives; wheezing, chest tightness, trouble breathing; swelling of your face, lips, tongue, or throat.

Zoledronic acid may cause serious side effects. Call your doctor at once if you have:

  • new or unusual pain in your thigh or hip;
  • jaw pain or numbness, red or swollen gums, loose teeth, or slow healing after dental work;
  • severe joint, bone, or muscle pain;
  • kidney problems–little or no urination, swelling in your feet or ankles, feeling tired;
  • low red blood cells (anemia)–pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet; or
  • low calcium levels–muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes).

Serious side effects on the kidneys may be more likely in older adults.

Common side effects of zoledronic acid may include:

  • trouble breathing;
  • nausea, vomiting, diarrhea, constipation;
  • bone pain, muscle or joint pain;
  • fever or other flu symptoms;
  • tiredness;
  • eye pain or swelling;
  • pain in your arms or legs;
  • headache; or
  • anemia.

Works

  • Zoledronate can help to make your bones stronger and reduce your risk of broken bones, including hip and spinal fractures.
  • Bones are made up of living tissue. The inside of our bones is constantly being broken down and rebuilt by specialist bone cells. As long as this process is in balance, your bones should stay healthy and strong.
  • But if the process becomes out of balance, our bodies can start to break down more bone than we build. This can cause the bones to become weaker and more likely to break easily.
  • Zoledronate works by slowing down the cells that break down bone. This helps to restore the balance and make your bones stronger.
  • You may still break a bone while taking zoledronate. If this happens, it doesn’t necessarily mean the drug isn’t working. No medication can stop all fractures, but taking zoledronate will make them much less likely.
  • Zoledronate is not a pain-relieving medicine, so it won’t reduce any pain caused by broken bones. But there are other treatments and ways to manage pain.

Direction of Use

  • Zoledronic acid is given as an infusion into a vein. A healthcare provider will give you this injection.
  • Zoledronic acid is sometimes given as a single dose only one time. It may also be given once every 1 or 2 years. How often you receive zoledronic acid will depend on why you are using this medicine. Follow your doctor’s instructions.
  • Drink at least 2 glasses of water within a few hours before your injection to keep from getting dehydrated.
  • You will need frequent medical tests.
  • Pay special attention to your dental hygiene while using zoledronic acid. Brush and floss your teeth regularly. If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are using zoledronic acid.
  • Zoledronic acid is only part of a complete program of treatment that may also include diet changes and taking calcium and vitamin supplements. Follow your doctor’s instructions very closely.
  • Your doctor will determine how long to treat you with this medicine. Zoledronic acid is often given for only 3 to 5 years.

Warning and Precaution

You should not be treated with zoledronic acid if you are allergic to it.

You should not be treated with zoledronic acid if are currently using any other bisphosphonate (such as alendronate, etidronate, ibandronate, pamidronate, risedronate, or tiludronate).

Tell your doctor if you have ever had:

  • kidney disease;
  • hypocalcemia;
  • thyroid or parathyroid surgery;
  • surgery to remove part of your intestine;
  • asthma caused by taking aspirin;
  • any condition that makes it hard for your body to absorb nutrients from food (malabsorption);
  • a dental problem (you may need a dental exam before you receive zoledronic acid);
  • if you are dehydrated; or
  • if you take a diuretic or “water pill”.

Zoledronic acid can cause serious kidney problems, especially if you are dehydrated, if you take diuretic medicine, or if you already have kidney disease.

zoledronic acid may cause jaw bone problems (osteonecrosis). The risk is highest in people with cancer, blood cell disorders, pre-existing dental problems, or people treated with steroids, chemotherapy, or radiation. Ask your doctor about your own risk.

You may need to have a negative pregnancy test before starting this treatment.

Do not use if you are pregnant. This medicine may harm an unborn baby or cause birth defects. Zoledronic acid can remain in your body for weeks or years after your last dose. Use effective birth control to prevent pregnancy while using this medicine. Talk with your doctor about the need to prevent pregnancy after you stop using zoledronic acid.

This medicine may affect fertility (ability to have children) in women. However, it is important to use birth control to prevent pregnancy because zoledronic acid can harm an unborn baby.

FAQ

Q1. What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your zoledronic acid injection.

Q2. What happens if I overdose?

Seek emergency medical attention.

Q3. What should I avoid while receiving zoledronic acid?

Avoid smoking, or try to quit. Smoking can reduce your bone mineral density, making fractures more likely.

Avoid drinking large amounts of alcohol. Heavy drinking can also cause bone loss.

Q4. What other drugs will affect zoledronic acid?

Zoledronic acid can harm your kidneys, especially if you also use certain medicines for infections, cancer, osteoporosis, organ transplant rejection, bowel disorders, high blood pressure, or pain or arthritis (including Advil, Motrin, and Aleve).

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